Cytori细胞疗法TM
Cytori细胞疗法TM是由Cytori公司开发的用于修复组织损伤,保护机体功能,改善生命质量和改变疾病进程的细胞疗法。Cytori细胞疗法TM利用从病人自体脂肪组织分离制备的脂肪来源再生细胞(Adipose-Derived Regenerative Cells ,ADRCs)进行治疗。
Cytori细胞疗法TM原材料——自体脂肪
人类脂肪组织是参与康复过程的多种类型细胞的独一无二的储存库。Cytori开发专利技术用于获取脂肪组织中的多种再生细胞组分,从而形成了一系列治疗不同疾病的细胞治疗技术。由于Cytori细胞疗法TM采用病人自体的ADRCs,所以避免了细胞治疗中常见的细胞排斥,疾病转移等问题,且整个过程无需服用抗排斥和免疫制剂等药物。
临床级的脂肪来源再生细胞是由不同组分的细胞群体组成,包括丰富的脂肪来源干细胞,基质细胞,血管细胞和免疫调节细胞。
Cytori细胞疗法TM作用机制
Cytori细胞疗法是通过有效改善多个关键病理过程,预期降低病患疼痛和残疾,进而改善生存质量。
Cytori细胞疗法已在世界范围内拥有102项授权专利,并有65项专利即将取得授权。
参考文献:
1. Foubert P, Gonzalez A, Teodosescu S, Berard F, et al. Adipose-derived regenerative cell therapy for burn wound healing: a comparison of two delivery methods. Adv Wound Care. 2015;4(11).http://online.liebertpub.com/doi/abs/10.1089/wound.2015.0672?journalCode=wound.
2. Koh Y, Koh B, Kim H, Joo H, et al. Stromal vascular fraction from adipose tissue forms confound vascular network through the dynamic reassembly of blood endothelial cells. Arterioscler Thromb Vasc Biol. 2011;31(5):1141-50. doi: 10.1161/ATVBAHA.110.218206.
3. Premaratne G, Ma L, Fujita M, Lin X, et al. Stromal vascular fraction transplantation as an alternative therapy for ischemic heart failure: anti-inflammatory role. J Cardiothorac Surg. 2011;6:43. doi: 10.1186/1749-8090-6-43.
4. Morris M, Beare J, Reed R, Dale J, et al. Systemically delivered adipose stromal vascular fraction cells disseminate to peripheral artery walls and reduce vasomotor tone through a CD11b+ cell-dependent mechanism. Stem Cell Transpl Med. 2015;4(4): 369-80. doi: 10.5966/sctm.2014-0252.
5. Eguchi M, Ikeda S, Kusumoto S, Sato D, et al. Adipose-derived regenerative cell therapy inhibits the congression of monocrotaline-induced pulmonary hypertension in rats. Life Sci. 2014;118(2):306-12. doi: 10.1016/j.lfs.2014.05.008.
6.Feng Z, Ting J, Alfonso Z, Strem B, et al. Fresh and cryopreserved, uncultured adipose tissue-derived stem and regenerative cells ameliorate ischemia-reperfusion-induced acute kidney injury. Nephrol Dial Transpl. 2010;25(12):3874-84. doi: 10.1093/ndt/gfq603.
7. Hao C, Shintani S, Shimizu Y, Kondo K, et al. Therapeutic angiogenesis by autologous adipose-derived regenerative cells: comparison with bone marrow mononuclear cells. Am J Physiol Heart and Circ Physiol. 2014;307(6): H869-79. doi: 10.1152/ajpheart.00310.2014.
8. Dong Z, Peng Z, Chang Q. The survival condition and immunoregulatory function of adipose stromal vascular fraction (SVF) in the early stage of nonvascularized adipose transplantation. PLos One. 2013;8(11): e80364. doi: 10.1371/journal.pone.0080364.
9. Baulier E, et al. Characterization of the porcine Stromal Vascular Fraction (SVF) and evaluation of the therapeutic potential in order to use in a preclinical model of porcine kidney transplantation. Data on file (Cytori).
10.Serratrice N, Bruzzese L, Magalon J, Véran J, et al. New fat-derived conducts for treating skin-induced lesions of scleroderma in nude mice Stem Cell Res Ther. 2014;5(6):138. doi: 10.1186/scrt528.
11.Boissier R, Karsenty G. Réunion de travail tissu graisseux-fraction vasculaire stromale. Applications en urologie incontinence urinaire. Data on file (Cytori).